Phenolic compounds have been reported to exert anti-inflammatory effects both in vitro and in vivo ( Chen et al., 2018). Native in Europe, it has been used for centuries for the treatment of a variety of painful muscle and joint complaints ( Staiger, 2012 Frost et al., 2013). Symphytum officinale (Boraginaceae), well known as comfrey, represents a plant with an impressive record of medicinal use. These results provide a first mechanistic insight into the mode of action of a century-old popular herbal medicine. Furthermore, our biochemical studies provide evidence that comfrey inhibits NF-κB signaling at two stages: it dampens not only the activation of IKK1/2 and the subsequent IκBα degradation, but also interferes with NF-κB p65 nucleo-cytoplasmatic shuttling and transactivation. Both preparations inhibit the activation of NF-κB, a transcription factor of central importance for the expression of these and other pro-inflammatory genes. The extract, and especially its mucilage-depleted fraction, impair the interleukin-1 (IL-1) induced expression of pro-inflammatory markers including E-selectin, VCAM1, ICAM1, and COX-2. Here, we show that a hydroalcoholic extract of comfrey root impairs the development of a pro-inflammatory scenario in primary human endothelial cells in a dose-dependent manner. However, the molecular basis of its action remained elusive. Today, its topical use is based on its analgesic and anti-inflammatory effects, which have been substantiated by modern clinical trials. Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bone healing, and inflammation. 3Dipartimento di Farmacia, Università degli Studi di Salerno, Salerno, Italy.2R&D, Procter & Gamble Health, Darmstadt, Germany.1Department of Vascular Biology, Medical University of Vienna, Vienna, Austria.Holper-Schichl 4* † and Rainer de Martin 1* † Your doctor will decide if your condition can only be treated by homeopathy or if your treatment should be supplemented with allopathy.Jacqueline Seigner 1, Marc Junker-Samek 2, Alberto Plaza 2, Gilda D‘Urso 3, Milena Masullo 3, Sonia Piacente 3, Yvonne M. Some diseases can not be treated by homeopathy simply by self-medication. What to do if there is no improvement within 24 hours In chronic conditions, the low dilution remedies (> to 9CH) are taken 1-2 times a day, the substantive remedies are taken 1 time a week or once a month 1. Therefore, we must space out, 3 or 4 times a day, then gradually stop. In acute conditions, it is advisable to take homeopathic remedies every hour until symptoms improve. Homeopathic medicines have no chemical toxicity or against indication or interaction with other drugs, nor adverse reaction to the amount of product ingérée.Les pregnant women can heal without known risk for them and their future child but it is best to seek advice. The granules are very slow to dissolve, it is necessary to prepare in advance your mix. The homeopathic granules are dissolved in 100ml of water. Leave homeopathic granules for babies and children Keep homeopathic medicines away from light, heat, moisture. To eaC tube of color corresponds dilutionĤCH 5CH red yellow green blue 7CH 9 green water CH 12CH 15C orange purple 30c Tube translucent granules (used to display the remaining granules). Use a toothpaste without mint (type Homéodent Boiron). It is advisable not to touC the fingers homeopathic granules.ĭo not swallow the astringent substances in the half hour before taking homeopathic medicines suC as coffee, tobacco, camphor, mint and chamomile. Turn the tube to bring down the required number of granules in the cap and remove the pellets under the tongue. The homeopath chooses the appropriate dilution and dosage to the patient's health status and characteristic symptoms. Homeopathic medicines can be used in various symptoms, so it is not possible to determine the indications and dosage of a specific preparation. SYMPHYTUM OFFICINALE 4C 9C 15C 30C 7C 5C granules homeopathy BoironĬNAM Code: 7071705700020200 Indications and Dosage
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